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4-Aminobutyric Acid Pharmacology
Feb 11, 2018


4-Aminobutyric Acid Pharmacology


Gamma-Aminobutyric Acid is a kind of natural active ingredient, which is widely distributed in plants and animals. It is fermented with the internationally recognized Lactobacillus. The purity exceeds 99%. Gamma aminobutyric acid, GABA, as a natural relaxation ingredient, can be used in common food and health food. Besides, Gamma-Aminobutyric Acid is also a kind of internationally recognized cosmetics raw material, it is listed in the international cosmetics raw materials directory.


GABA is a natural non-protein amino acid. It is the most important inhibitory neurotransmitter in the brain. Having enough GABA in our brain is a guarantee of being relaxed and happy. Lack of GABA will cause the sleeping problem, anxious and tense feelings. Testing brain waves is widely used to evaluate if people feel relaxed or nervous. Alpha waves are linked to relaxation, clear thinking and good focus. Beta waves are linked to stress and anxiety. Clinical trials show that taking GABA can increase the amount of alpha waves and reduce beta waves. So oral GABA can help people feel relaxed and happy.


Drugs, that act as allosteric modulators of GABA receptors (known as GABA analogues or GABAergic drugs) or increase the available amount of GABA, typically have relaxing, anti-anxiety, and anti-convulsive effects. Many of the substances below are known to cause anterograde amnesia and retrograde amnesia.

 GABA directly injected to the brain has been reported to have both stimulatory and inhibitory effects on the production of growth hormone, depending on the physiology of the individual. Certain pro-drugs of GABA (ex. picamilon) have been developed to permeate the blood-brain barrier, then separate into GABA and the carrier molecule once inside the brain. This allows for a direct increase of GABA levels throughout all areas of the brain, in a manner following the distribution pattern of the pro-drug prior to metabolism.

GABA enhanced the catabolism of serotonin into N-acetylserotonin (the precursor of melatonin) in rats. It is thus suspected that GABA is involved in the synthesis of melatonin and thus might exert regulatory effects on sleep and reproductive functions.


Because of its calming and soothing effect, oral gamma-aminobutyric acid can reduce stress and promote sleep. 


Furthermore, it is proved by numerous studies that oral GABA can help lower blood pressure and enhance focus and concentration.


Gamma-Aminobutyric Acid quickly penetrates into the skin, relaxing tense muscles and reducing small wrinkles and lines. After using the eye cream containing GABA, the anti-wrinkle effects were obvious and observed within 30 minutes. 


Crow's feet and small expression lines on the cheek were significantly reduced. The anti-wrinkle effects sustained for 8 hours, the average depth of wrinkles can be reduced by 12.34% after 4 weeks.







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