Knowledge

Home > Knowledge > Content
Histidine properties
Sep 01, 2017

α-amino β-imidazolyl propionic acid, belonging to basic amino acids or heterocyclic amino acids. Reaction with Pa-uli reacts with diazonium sulfonic acid to produce red. There are D, D, L and aphids (L for Latin left meaning, D is Latin DEXTRO, right meaning, D, L refers to the molecular structure of the amino acid chirality) exists in the globin. There is also a muscle peptide component in the muscle. L-histidine colorless flaky or needle-like crystals, odorless, slightly bitter. 227 ° C softened, 277 ° C decomposition. Dissolved in water. Optical rotation - 39.4 ° (c = 1.13, water). To dry flour, pigs, bovine blood meal, pig hair or hoof made of raw materials, but also by the fermentation of glucose. Histidine Compared with other amino acids, in addition to some common chemical reactions, due to its right chain imidazolyl and diazonium benzenesulfonic acid can form a reddish red compound, that is, Polly (Pauly) reaction. Since the dissociation constant of imidazolyl is 6.0, the dissociated proton concentration is similar to that of water, so histidine can be used as proton donor and as proton acceptor.

On the other hand, imidazolyl is supplied to protons and accept protons at a very fast rate, with a half-life of less than 10-10s, and the rate of supply to protons and protons is almost equal. Histidine residues are often active in active proteins. Histidine is a semi-essential amino acid and can be used as a drug or biochemical reagent. For the human body, histidine can be a common intermediate metabolites, and therefore has been considered non-essential amino acids, but with the depth of the study, it was found that young animals and infants in the synthesis of histidine can not meet the body's growth needs, Even adult animals, if not from the food to add, in vivo synthesis can not meet the needs, so people call it semi-essential amino acids.

Histidine is also one of the essential raw materials for the synthesis of some pharmaceutical intermediates, such as blue copper peptides ghk-cu.

It has been known that the major metabolic pathways in the organism are deamination by histidine deaminase, histamine formation through the decarboxylase, and amino transfer reactions. Biosynthesis is the formation of imidazole glycerophosphate from ATP adenine and phosphoric acid ribose phosphate for amino conversion.

L-histidine is a semi-essential amino acid that is particularly important for infants and animals. Can be used as biochemical reagents and pharmaceuticals, but also for the treatment of heart disease, anemia, rheumatoid arthritis and other drugs. Histidine is present in bananas, grapes, meat, poultry, milk and dairy products. In addition, histidine is also present in green vegetables, but less.








Copyright © Shandong Yangcheng Biotech Co.,Ltd All Rights Reserved.Tel: +86-537-2318768