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Basic Knowledge Of Amino Acids
Sep 01, 2017

1. what are the methods for the preparation of amino acids?

The preparation of amino acids mainly consists of three ways: protein hydrolysis, organic synthesis and fermentation.

2. what is the amino acid type D, L type, DL type? What is called amino acid protection?

D, L refers to the conformation of amino acids. According to the theory, according to the calculation can be divided into L type and D type (L and D are the Latin prefix, D is right, L is left). Natural amino acids are L type, except for Gly, no 3.

DL is also meso amino acid, because of the simultaneous existence of D and L type carbon atoms. Generally only for a carbon, so there is generally no such DL type statement.

Amino acid protection: refers to the functional groups of amino acids and other groups reaction, and closed the amino acid functional groups of active amino acid derivatives, can be called protective amino acids. Including a, amino and carboxyl groups, and side chain functional groups.

3. what are the carboxyl protective groups in amino acids?

They are tert butyl, methyl, ethyl, benzyl, allyl, five fluorine phenyl groups, methyl benzyl, and so on

What are the amino protection groups in 4. amino acids?

General t-Boc, 9-fluorenylmethoxycarbonyl, alloc, three fluorine carbethoxy, n-benzyloxycarbonyl-l-glutamic, carbethoxy, p-tolylsulfonyl, phthalate two formyl, etc..

5. what are the categories of commonly used amino acids?

20 kinds of common amino acids, the side chain can be divided into several categories: aliphatic amino acids (Ala, Gly, Val, Leu, Ile), aromatic amino acids (Phe, Tyr, Trp, His), amide or carboxyl side chain amino acids (Asp, Glu, Asn, Gln), Lys (alkaline amino acid side chain, Arg), sulfur amino acid (Cys, Met), alcohol containing amino acids (Ser, Thr), ammonia acid (Pro).

6. what is the use of amino acid based protection?

The protection of amino acids in chemical synthesis of peptides is crucial, and directly determines the key to the success of synthesis. Because the 20 common amino acids are activated with side chain, need to be protected, the general requirements, the protection of the foundation stability in the synthesis process, no adverse reaction, after the removal of synthesis can be completely quantitative.

The amino acids that need to be protected in synthesis include: Cys, Asp, Glu, His, Lys, Asn, Gln, Arg, Trp, Ser, Thr, Tyr.

The need for protection of the hydroxyl group, carboxyl group, amino, thiol, amide, guanidine, indole, imidazole etc.. Trp is also not protected because of the relatively stable nature of indole. Of course, in particular cases, some amino acids can not be protected, such as Asn, Gln, Thr, Tyr.

What are the common methods to protect 7. OC based?

Three kinds, one is three fluorine acetic acid law, more commonly used, two is concentrated hydrochloric acid method, three is silica gel catalysis method.





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