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Physicochemical Properties Of 4 - Aminobutyric Acid Chemical
Sep 01, 2017

4- aminobutyric acid source

As a chemical, GABA was synthesized as early as 1883. In 1950, it was found that the concentration of GABA in the normal brain of mammals was high, but the physiological significance was unknown. Then, some people from bovine brain extract can inhibit a crayfish stretch receptor neuron impulse extract, its anti acetylcholine and pulse of rats and rabbits were ileum contraction, and prove that the extract inhibited the component is GABA. SegalSA also confirmed that GABA is generally in mammalian central nervous inhibition with ion electrophoresis GABA separated from the surrounding cortex of cat cross channel injection of neurons, hyperpolarization can cause neurons, inhibitory potential and its potential to stimulate the cortical surface synapses generated by the same, and found that the cerebellar Purkinje cells by electrical stimulation the cat of the fourth ventricle perfusion GABA content in solution increased 3 times, so that neurotransmitters in Purkinje neurons release is GABA.

4-butyric acid, physical and chemical properties

Lobular crystalline (methanol ether), needle like crystals (water ethanol), melting point 202 DEG C (decomposed under rapid heating). At 25 DEG C, the dissociation constant Ka3.7 x 10-11, Kb1.7 * 10-10. Soluble in water, slightly soluble in hot ethanol, insoluble in other organic solvents. The decomposition of pyrrole and water at temperatures above the melting point. Appearance: white crystalline or crystalline powder.

White flake or needle crystal; deliquescence; slight odor, easily soluble in water, slightly soluble in ethanol, insoluble in ethanol, ether and benzene; decomposition point of 202 DEG C; LD50 (rat peritoneal 5400mg/kg).





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